Navigating skin side effects of cancer treatment:

Understanding and managing

Cancer treatment brings hope but also presents challenges, especially for the skin. Chemotherapy, radiotherapy, and targeted therapies can cause various skin reactions, affecting patients’ well-being.

In this blog, we’ll explore common skin-related adverse reactions to cancer therapies.

Nail Toxicities

Ever heard of paronychia or periungual pyogenic granuloma? These nail problems may arise during certain cancer treatments, and while they may not be severe, they can certainly be bothersome. Understanding the differences between chemotherapy and targeted therapy-associated nail toxicities is essential for effective management. While not usually severe, these lesions can significantly affect patients’ quality of life. Therefore, implementing strategies to manage them is essential¹.

Acneiform Rash

An acneiform rash, often associated with medications targeting epidermal growth factor receptor and MAP kinase signaling pathways can lead to papules, pustules, and intense itchiness. This rash can profoundly impair patients’ quality of life¹.

Hyperpigmentation

Hyperpigmentation, another common adverse reaction, manifests as darkening of the skin due to various mechanisms. It’s a common side effect of certain cancer drugs, like 5-fluorouracil and cisplatin, but it’s not permanent².

Xerosis

Xerosis, or dry skin, is a prevalent concern among oncology patients, often attributed to impaired sebaceous gland function. Drugs like cyclophosphamide and carboplatin are associated with this side effect. Providing patients with guidance on the liberal application of emollients and adopting hydration practices can effectively reduce discomfort².